関西医科大BRAND

関西医科大学

本学は、建学の精神に則り、自由・自律・自学の学風のもと、学問的探究心を備え、幅広い教養と国際的視野をもつ人間性豊かな良医を育成することを教育の理念としています。

慈仁心鏡
慈仁心鏡、すなわち慈しみ・めぐみ・愛を心の規範として生きる医人を育成することを建学の精神とする。

関連施設

  • 附属病院
  • 総合医療センター
  • 香里病院
  • 天満橋総合クリニック
  • 附属看護専門学校
  • 卒後臨床研修センター
疾患モデル動物センター

疾患モデル動物センター 

疾患モデル動物センター 研究業績

(薬理学)

*1.   Fujikawa Y, Yoshida H, Inoue T, Ohbayashi T, Noda K, von Melchner H, Iwasaka T, Shiojima I, Akama TO, Nakamura T, Latent TGF-β binding protein 2 and 4 have essential overlapping functions in microfibril development. Sci. Rep. レフェリー有 7:43714, 2017.

2.   Kageshima M, Maruyama T, Akama T, Nakamura T, Novel magnetic indenter for rheological analysis of thin biological sheet for regenerative medicine. Rev. Sci. Instrum. レフェリー有 87:074302, 2016.

*3.   Inoue T, Ohbayashi T, Fujikawa Y, Yoshida H, Akama TO, Noda K, Horiguchi M, Kameyama K, Hata Y, Takahashi K, Kusumoto K, Nakamura T, Latent TGFβ binding protein-2 is essential for the development of ciliary zonule microfibrils. Hum Mol Genet. レフェリー有 23(21):5672-82. 2014.

*4.   Noda K, Dabovic B, Takagi K, Inoue T, Horiguchi M, Hirai M, Fujikawa Y, Akama TO, Kusumoto K, Zilberberg L, Sakai LY, Koli K, Naitoh M, von Melchner H, Suzuki S, Rifkin DB, Nakamura T, Latent TGFβ binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5. Proc. Natl. Acad. Sci. USA レフェリー有 110(8):2852-7, 2013.

 

(分子遺伝学部門)

*5.   Kondo N, Ueda Y, Kita T, Ozawa M, Tomiyama T, Yasuda K, Lim DS, Kinashi T. NDR1-dependent regulation of kindlin-3 controls high-affinity LFA-1 binding and immune synapse organization. Mol Cell Biol. レフェリー有 2017 Jan 30. pii: MCB.00424-16. doi: 10.1128/MCB.00424-16. [Epub ahead of print] 2017

*6.   Ueda Y, Kondo N, Ozawa M, Yasuda K, Tomiyama T, Kinashi T, Sema3e/Plexin D1 Modulates Immunological Synapse and Migration of Thymocytes by Rap1 Inhibition. J Immunol. レフェリー有196(7):3019-31.2016

*7.   Yasuda K, Ueda Y, Ozawa M, Matsuda T, Kinashi T, Enhanced cytotoxic T cell function and inhibition of tumor progression by Mst1 deficiency. FEBS Letter レフェリー有590(1):68-75. 2016.

*8.   Fukuhara T, Tomiyama T, Yasuda K, Ueda Y, Ozaki Y, Son Y, Nomura S, Uchida K, Okazaki K, Kinashi T. Hypermethylation of MST1 in IgG4-related autoimmune pancreatitis and rheumatoid arthritis. BBRC. 463(4):968-74. 2015.

*9.   Katakai T, Kondo N, Ueda Y, and Kinashi T, Autotaxin Produced by Stromal Cells Promotes LFA-1–Independent and Rho-Dependent Interstitial T Cell Motility. J Immunol レフェリー有193:617-626, 2014

*10.  Katakai T, Habiro K, Kinashi T. Dendritic Cells Regulate High-Speed Interstitial T Cell Migration in the Lymph Node via LFA-1/ICAM-1. J Immunol レフェリー有191(3):1188-99. 2013

*11.  Tomiyama T, Ueda Y, Katakai T, Kondo N, Okazaki K, Kinashi T. Antigen-specific suppression and immunological synapse formation by regulatory T cells require the mst1 kinase. PLoS One. レフェリー有8(9):e73874, 2013.

*12.  Ueda Y, Katagiri K, Tomiyama T, Yasuda K, Habiro K, Katakai T, Ikehara S, Matsumoto M, Kinashi T, Mst1 regulates integrin-dependent thymocyte trafficking and antigen-recognition in the thymus. Nat. Commun. レフェリー有3:1098. 2012

 

(内科学第三)

*13.  Sakao M, Sakaguchi Y, Suzuki R, Takahashi Y, Kishimoto M, Fukui T, Uchida K, Nishio A, Matsuzaki K, Okazaki K. Smad2/3 Linker Phosphorylation Is a Possible Marker of Pancreatic Stem/Progenitor Cells in the Regenerative Phase of Acute Pancreatitis. Pancreas. レフェリー有46:605-613. 2017

14.   Arai Y, Yamashita K, Kuriyama K, Shiokawa M, Kodama Y, Sakurai T, Mizugishi K, Uchida K, Kadowaki N, Takaori-Kondo A, Kudo M, Okazaki K, Strober W, Chiba T, Watanabe T. Plasmacytoid Dendritic Cell Activation and IFN-α Production Are Prominent Features of Murine Autoimmune Pancreatitis and Human IgG4-Related Autoimmune Pancreatitis. J Immunol. レフェリー有195(7):3033-44. 2015

*15.  Toyonaga T, Nakase H, Ueno S, Matsuura M, Yoshino T, Honzawa Y, Itou A, Namba K, Minami N, Yamada S, Koshikawa Y, Uede T, Chiba T, Okazaki K. Osteopontin Deficiency Accelerates Spontaneous Colitis in Mice with Disrupted Gut Microbiota and Macrophage Phagocytic Activity. PLoS One. レフェリー有10(8):e0135552. 2015

16.   Fukuhara T, Tomiyama T, Yasuda K, Ueda Y, Ozaki Y, Son Y, Nomura S, Uchida KOkazaki K, Kinashi T. Hypermethylation of MST1 in IgG4-related autoimmune pancreatitis and rheumatoid arthritis. レフェリー有Biochem Biophys Res Commun. 463(4):968-74. 2015

17.   Suzuki R, Fukui T, Kishimoto M, Miyamoto S, Takahashi Y, Takeo M, Mitsuyama T, Sakaguchi Y, Uchida K, Nishio A, Okazaki K.  Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer.  J Crohns Colitis. レフェリー有9:565-74 2015

*18.  Okazaki T, Nishio A, Takeo M, Sakaguchi Y, Fukui T, Uchida KOkazaki K.  Inhibition of the Dephosphorylation of Eukaryotic Initiation Factor 2α Ameliorates Murine Experimental Colitis.  Digestion. レフェリー有90(3):167-178 2014

 

(微生物学)

19.   Fujisawa J, Lee SI, Yao J, Ren Y, Tanaka M. Tax peptide vaccine suppressed the leukemia in humanized mouse. Retrovirology レフェリー無, 12(Suppl1), O43, 2015

*20   Tezuka K, Xun R, Tei M, Ueno T, Tanaka M, Takenouchi N and Fujisawa J, An animal model of adult T-cell leukemia: humanized mice with HTLV-1-specific immunity. Blood レフェリー有 123, 346-355, 2014

21.   Tezuka T, Tei M, Ueno T, Xun R, Fujisawa J, Carrier model of HTLV-1 infection in humanized NOG mice. Retrovirology  レフェリー無 11(Suppl1), P43, 2014

22.   Tezuka T, Tei M, Ueno T, Xun R, Iha H, Fujisawa J, Inhibition of ATL development in humanized mouse model by AZT/INF treatment. Retrovirology  レフェリー無, 11(Suppl1), P43, 2014

*23.  Ikebe E, Kawaguchi A, Tezuka K. Taguchi S. Hirose S, Matsumoto T, Mitsui , Senba K, Nishizono A, Hori M, Hasegawa H, Yamada Y, Ueno T, Tanaka Y, Sawa H, Hall W, Minami Y, Jeang K-T, Ogata M, Morishita K, Hasegawa H, Fujisawa J, and Iha H, Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell in filtrationin to multiple organs and improves survival period for ATL model mice. Blood Cancer Journal  レフェリー有 3, e132(ページなし), 2013

 

(衛生学)

*24.  Matsuoka Y, Takahashi M, Sumide K, Kawamura H, Nakatsuka R, Fujioka T, Sonoda Y, CD34 Antigen and the MPL Receptor Expression Defines A Novel Class Of Human Cord Blood-Derived Primitive Hematopoietic. Stem Cells. Cell Transplantation, レフェリー有in press. 

*25.  Matsuoka Y, Sumide K, Kawamura H, Nakatsuka R, Fujioka T, Sonoda Y: GPI-80 Expression Highly Purifies Human Cord Blood-derived Primitive CD34-negative Hematopoietic Stem Cells. Blood レフェリー有128(18):2258-2260,2016.

*26.  Matsuoka Y, Nakatsuka R, Sumide K, Kawamura H, Takahashi M, Fujioka T, Uemura Y, Asano H, Sasaki Y, Inoue M, Ogawa H, Takahashi T, Hino M, Sonoda Y: Prospectively Isolated Human Bone Marrow Cell-derived MSCs Support Primitive Human CD34-negative Hematopoietic Stem Cells. Stem Cells レフェリー有33:1554-1565, 2015.

27.   Matsuoka Y, Sumide K, Kawamura H, Nakatsuka R, Fujioka T, Sasaki Y, Sonoda Y: Human Cord Blood-derived CD34-negative Hematopoietic Stem Cells (HSCs) are Myeloid-biased Long-term Repopulating HSCs. Blood Cance J , レフェリー有5:e290;doi:10.1038/bcj. 2015.  

*28.  Takahashi M, Matsuoka Y, Sumide K, Nakatsuka R, Fujioka T, Kohno H, Sasaki Y, Matsui K, Asano H, Kaneko K, Sonoda Y: CD133 is a Positive Marker for a Distinct Class of Primitive Human Cord Blood-derived CD34–negative Hematopoietic Stem Cells. Leukemia レフェリー有28:1308-1315, 2014.

 

(生体情報部門)

29.   Hoshii T, Kasada A, Hatakeyama T, Ohtani M, Tadokoro Y, Naka K, Ikenoue T, Ikawa T, Kawamoto H, Fehling HJ, Araki K, Yamamura K, Matsuda S, and Hirao A,  Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells.  Proc. Natl. Acad. Sci. USA. レフェリー有 111: 3805-3810.2014

30.   Hirata Y, Sugie A, Matsuda A, Matsuda S, and Koyasu S,  TAK1-JNK axis mediates survival signal through Mcl1 stabilization in activated T cells.  J. Immunol. レフェリー有 190: 4621-4626. 2013

31.   Takayama G, Ohtani M, Minowa A, Matsuda S, and Koyasu S,  Class I PI3K-mediated Akt and ERK signals play a critical role in FcεRI-induced degranulation in mast cells. Int. Immunol. レフェリー有 25: 215-220. 2013

*32.  Ohtani M, Hoshii T, Fujii H, Koyasu S, Hirao A, and Matsuda S,  mTORC1 in intestinal CD11c+CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production. J. Immunol. レフェリー有 188: 4736-4740. 2012

33.   Kurebayashi Y, Nagai S, Ikejiri A, Ohtani M, Ichiyama K, Baba Y, Yamada T, Egami S, Hoshii T, Hirao A, Matsuda S, and Koyasu S,  PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi-1 expression and nuclear translocation of RORγ  Cell Reports レフェリー有 1: 360-373. 2012

 

(医化学)

*34.  Uchida H, Matsumura S, Okada S, Suzuki T, Minami T, and Ito S, RNA editing enzyme ADAR2 is a mediator of neuropathic pain after peripheral nerve injury. FASEB J. レフェリー有in press, 2017.

*35.  Hayashi M, Shinozuka Y, Shigenobu S, Sato M, Sugimoto M, Ito S, Abe K, and Kobayashi S, Conserved role of Ovo in germline development in mouse and Drosophila. Sci. Rep. レフェリー有7, 40056, 2017.

*36.  Katano T, Fukuda M, Furue H, Yamazaki M, Abe M, Watanabe M, Nishida K, Yao I, Hata Y, Okumura N, Nakazawa T, Yamamoto T, Sakimura K, Takao Y, Ito S. Involvement of brain-enriched guanylate kinase-associated protein (BEGAIN) in chronic pain after peripheral nerve injury. eNeuro, レフェリー有3, e0110-16(1-18), 2016.

*37.  Lee B, Villarreal-Ponce A, Fallahi M, Ovadia J, Sun P, Yu QC, Ito S, Sinha S, Nie Q, and Dai X, Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells. Dev. Cell レフェリー有29, 47-58, 2014.

*38.  Okuda-Ashitaka E, Minami T, Tsubouchi S, Kiyonari H, Iwamatsu A, Noda T, Handa H, and Ito S, Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission. J. Biol. Chem. レフェリー有287, 10403-10413, 2012.

 

(神経機能部門)

39.   Sato T, Kobayakawa R, Kobayakawa K, Emura M, Itohara S, Kizumi M, Hamana H, Tsuboi A, Hirono H. Supersensitive detection and discrimination of enantiomers by dorsal olfactory receptors: evidence for hierarchical odour coding. Scientific Reports レフェリー有5: 14073. 2015

*40.  Isosaka T, Matsuo T, Yamaguchi T, Funabiki K, Nakanishi S, Kobayakawa R*, Kobayakawa K*. Htr2a-expressing cells in the central amygdala control the hierarchy between innate and learned fear. (* corresponding authors) Cell レフェリー有163, 1153-1164. 2015

41.   Sato T, Kobayakawa R, Kobayakawa K, Emura M, Itohara S, Kawasaki M, Tsuboi A & Hirono J. Supersensitive odor discrimination is controlled in part by initial transient interactions between the most sensitive dorsal olfactory receptors and G-proteins. Receptors & Clinical Investigation レフェリー有3, e1117. 2016

 

(病理学第一)

42.   Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, and Kuo CJ. Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem cell self-renewal, Nature. レフェリー有545(7653):238-242. 2017

*43.  Yanai H, Atsumi N, Tanaka T, Nakamura N, Komai Y, Omachi T, Tanaka K, Ishigaki K, Saiga K, Ohsugi H, Tokuyama Y, Imahashi Y, Ohe S, Hisha H, Yoshida N, Kumano K, Kon M and Ueno H. Intestinal cancer stem cells marked by Bmi1 or Lgr5 expression contribute to tumor propagation via clonal expansion. Sci. Rep.  レフェリー有 8;7:41838.  2017

*44.  Tanaka T, Atsumi N, Nakamura N, Yanai H, Komai Y, Omachi T, Tanaka K, Ishigaki K, Saiga K, Ohsugi H, Tokuyama Y, Imahashi Y, Hisha H, Yoshida N, Kumano K, Okazaki K, and Ueno H.(2016)Bmi1-positive cells in the lingual epithelium could serve as cancer stem cells in tongue cancer. Sci. Rep. レフェリー有り 6:39386. 2016

*45.  Ueno H. Identification of normal and neoplastic stem cells by the multicolor lineage tracing method. Pathol. Int. レフェリー有 66(8)423-430.2016

46.   Hisha H, Tanaka T, Ueno H. Lingual Epithelial Stem Cells and Organoid Culture of Them. Int. J. Mol. Sci. レフェリー有 17(2). pii: E168. 2016

 

  (2017年度以降の業績)

1. Hirotsugu Yanai, Naho Atsumi, Toshihiro Tanaka, Naohiro Nakamura,Yoshihiro Komai, Taichi Omachi, Kiyomichi Tanaka, Kazuhiko Ishigaki, Kazuho Saiga, Haruyuki Ohsugi, Yoko Tokuyama, Yuki Imahashi, Shuichi Ohe, Hiroko Hisha, Naoko Yoshida, Keiki Kumano, Masanori Kon, and UenoH.(2017)Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity. Scientific Reports  in press

 2.  Jinshu Xu, H Ueno ,Chelsea Xu, Binglai Chen, Irving Weissman, and
Pin-Xian Xu(2017). Nature Communications  DOI: 10.1038/ncomms15046

 (病理学第二)

*47.   Emoto Y, Yoshizawa K, Kinoshita Y, Yuki M, Yuri T, Tsubura A. Susceptibility to N-methyl-N-nitrosourea-induced retinal degeneration in different rat strains. J Toxicol Pathol. レフェリー有29(1):67-71. 2016

*48.   Emoto Y, Yoshizawa K, Kinoshita Y, Yuki M, Yuri T, Tsubura A.Green tea extract attenuates MNU-induced photoreceptor cell apoptosis via suppression of heme oxygenase-1.  J Toxicol Pathol. レフェリー有29(1):61-5. 2016.

*49.   Kinoshita Y, Yoshizawa K, Emoto Y, Yuki M, Yuri T, Shikata N, Elmore SA, Tsubura A, A spontaneously occurring malignant ovarian Sertoli cell tumor in a young Sprague Dawley rat. J Toxicol Pathol. レフェリー有29(1):53-9. 2016.

*50.   Emoto Y, Yoshizawa K, Kinoshita Y, Yuki M, Yuri T, Yoshikawa Y, Sayama K, Tsubura A. Green tea extract-induced acute hepatotoxicity in rats and a literature review. J Toxicol Pathol レフェリー有27(3-4):163-74. 2014

*51.   Yoshizawa K, Uehara N, Kimura A, Emoto Y, Kinoshita Y, Yuri T, Takada H, Moriguchi T, Hamazaki T, Tsubura A. Promoting effect of arachidonic acid supplementation on N-methyl-N-nitrosourea-induced pancreatic acinar cell hyperplasia in young Lewis rats. Oncol Lett レフェリー有 5(1): 76-82, 2013.

*52.  Yoshizawa K, Emoto Y, Kinoshita Y, Kimura A, Uehara N, Yuri T, Tsubura A. Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal preneoplastic lesions in young Lewis rats. Oncol Lett  レフェリー有5(4): 1112-1116, 2013.

 

(モデル動物部門)

*53.   Ueda Y, Kondo N, Ozawa M, Yasuda K, Tomiyama T, Kinashi T, Sema3e/Plexin D1 Modulates Immunological Synapse and Migration of Thymocytes by Rap1 Inhibition. J Immunol. レフェリー有. 196(7):3019-31. 2016.

*54.   Yasuda K., Ueda Y., Ozawa M., Matsuda T., Kinashi T., Enhanced cytotoxic T cell function and inhibition of tumor progression by Mst1 deficiency. FEBS Letter. レフェリー有. 590(1):68-75. (2016) doi: 10.1002/1873-3468.12045.

55.   安齋政幸、井上達也、西村愛美、野田義博、東里香、梶本みずき、三谷匡、細井美彦. β-Nicotinamide mononucleotideを添加したマウス体外成熟培地が未成熟卵子内への活性酸素種(ROS)に与える影響. 日本受精着床学会雑誌. レフェリー有. 33:21-26.2016.

56.    井上達也、東里香、野田義博、西村愛美、梶本みずき、小橋朱里、折杉卓哉、安齋政幸. L-カルニチン添加体外成熟培地がマウス卵子細胞質内活性酸素種に与える影響. 近畿大学先端技術総合研究所紀要. レフェリー有. 21:49~56.

*57.   Nishikimi A, Ishihara S, Ozawa M, Etoh K,Fukuda M, Kinashi T, Katagiri K. Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking. Sci. Signal. レフェリー有.7:ra72 (2014) DOI: 10.1126/scisignal.2005199

 

(解剖学第一)

58.    Hirahara Y, Wakabayashi T, Mori T, Koike T, Yao I, Tsuda M, Honke K, Gotoh H, Ono K, Yamada H.Sulfatide species with various fatty acid chains in oligodendrocytes at different developmental stages determined by imaging mass spectrometry.J Neurochem レフェリー有140(3): 435-450, 2017.

59.   Tanaka S, Takizawa N, Honda Y, Koike T, Oe S, Toyoda H, Kodama T, Yamada H, Hypocretin/orexin loss changes the hypothalamic immune response. Brain Behav Immun レフェリー有57: 58-67, 2016.

*60.   Koike T, Wakabayashi T, Mori T, Takamori Y, Hirahara Y, Yamada H , Sox2 in the adult rat sensory nervous system. Histochem Cell Biol レフェリー有141(3): 301-309, 2014.

61.    Mori T, Wakabayashi T, Ogawa H, Hirahara Y, Koike T, Yamada H, Increased histone h3 phosphorylation in neurons in specific brain structures after induction of status epilepticus in mice. PLoS ONE レフェリー有8(10): Article No.e77710, 2013.

*62.   Hirahara Y, Matsuda KI, Yamada H, Saitou A, Morisaki S, Takanami K, Boggs JM, Kawata M. G protein-coupled receptor 30 contributes to improved remyelination after cuprizone-induced demyelination. Glia レフェリー有 61(3):420-431 2013

 

(解剖学第二)

63.   Trifonov S, Yamashita Y, Kase M, Maruyama M, Sugimoto T. Overview and assessment of the histochemical methods and reagents for the detection of b-galactosidase activity in transgenic animals. Anatomical Science International. レフェリー有91 (1):56-67.2016

64.  Trifonov S, Yamashita Y, Kase M, Maruyama M, Sugimoto T. Glutamic acid decarboxylase 1 alternative splicing isoforms: characterization, expression and quantification in the mouse brain. BMC Neuroscience. レフェリー有15(1):Article No. 114.2014

*65.  Maruyama M, Yamashita Y, Kase M, Trifonov S, Sugimoto T. Lineage-Specific Purification of Neural Stem/Progenitor Cells From Differentiated Mouse Induced Pluripotent Stem Cells. Stem Cells Translational Medicine. レフェリー有2 (6):420-433.2013

66.   Trifonov S, Houtani T, Kase M, Toida K, Maruyama M, Yamashita Y, Shimizu J, Sugimoto T. Lateral regions of the rodent striatum reveal elevated glutamate decarboxylase 1 mRNA expression in medium-sized projection neurons. Eur. J. Neurosci. レフェリー有35(5):711-722.2012

67.   Horie A, Fujiwara H, Sato Y, Suginami K, Matsumoto H, Maruyama M, Konishi I, Hattori A. Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation. Human Reproduction. レフェリー有27 (5):1267-1276.2012

 

(生理学第二)

68.   Balasubraman P, Chakravarthy S, Wong-Lin K, Wang D, Cohen J Y, Nakamura K, and Moustafa A, Neural circuit models of serotonergic system: From microcircuits to cognition. In A. Moustafa (Ed.) Computational models of Brain and Behavior. Wiley-Blackwell. In press. 2017

69.   Wong-Lin K, Wang D, Moustafa A, Cohen J. and Nakamura K, "Toward a multiscale modeling framework for understanding serotonergic function" in its current form for publication in the Journal of Psychopharmacology. In press 2017

70.   Yamada H, Inokawa H, Hori Y, Pan X, Matsuzaki R, Nakamura K, Samejima K, Shidara M, Kimura  M, Sakagami M, Minamimoto T,  Characteristics of fast-spiking neurons in the striatum of behaving monkeys. Neurosci Res. 105:2-18. 2016

71.   中村加枝 林和子 中尾和子 背側縫線核による報酬・嫌悪情報処理 日本薬理学雑誌 vol149 2017

 

(生物学)

72.   Schoch H, Kreibich AS, Ferri SL, White RS, Bohorquez D, Banerjee A, Port RG, Dow HC, Cordero L, Pallathra AA, Kim H, Li H, Bilker WB, Hirano S, Schultz RT, Borgmann-Winter K, Hahn CG, Feldmeyer D, Carlson GC, Abel T, Brodkin ES.  Sociability Deficits and Altered Amygdala Circuits in Mice Lacking Pcdh10, an Autism Associated Gene. Biol Psychiatry. レフェリー有 81(3):193-202. 2017

 

(公衆衛生学)

73.   王 澤蘊神田靖士下埜敬紀、ヴィエンバリー フォンマニボン、西山利正、ラット下垂体腫瘍細胞MtT/Seを用いた漢方製剤のエストロゲン様作用の検討、産婦人科 漢方研究のあゆみ、レフェリー有 33:3639.2016.4

74.   Hosomi R, Otsuka R, Arai H, Kanda S, Nishiyama T, Yoshida M, Fukunaga K.Porcine Hemoglobin Promotes Lipid Excretion to Feces more Strongly than Globin Protein in Rats. Food Sci. Biotechnol. レフェリー有. 25(S): 107-112, 2016

75.   Fukunaga K, Hosomi R, Fukao M, Miyauchi K, Kanda S, Nishiyama T, Yoshida M. Hypolipidemic Effects of Phospholipids (PL) Containing n-3 Polyunsaturated Fatty Acids (PUFA) Are Not Dependent on Esterification of n-3 PUFA to PL. Lipids. レフェリー有. 51279-289 January 2016

76.   Ooka H, Kanda S, Okazaki H, Suzuki H, Mishima K, Saito I, Yagi M, Tomoda K, Nishiyama T, Characterization of side population (SP) cells in murine cochlear nucleus. Acta Otolaryngol. レフェリー有. 132(7):693-701, 2012.7.

77.   Osumi Y, Shibata SB, Kanda S, Yagi M, Ooka H, Shimano T, Asako M, Kawamoto K, Kuriyama H, Inoue T, Nishiyama T, Yamashita T, Tomoda K, Characterization of side population (SP) cells in murine cochlear nucleus. Brain Res. レフェリー有. 1454:23-32, 2012.5

 

(外科学)

*78.  Kim S, Toyokawa H, Yamao J, Satoi S, Yanagimoto H, Yamamoto T, Hirooka S, Yamaki S, Inoue K, Matsui Y, Kwon AH. Antitumor Effect of Angiotensin II Type 1 Receptor Blocker Losartan for Orthotopic Rat Pancreatic Adenocarcinoma. Pancreas. レフェリー有・43(6): 886-890. 2014

*79.  Yamao J, Toyokawa H, Kim S, Yamaki S, Satoi S, Yanagimoto H, Yamamoto T, Hirooka S, Matsui Y, Kwon AH. Activation of alpha-smooth muscle actin-positive myofibroblast-like cells after chemotherapy with gemcitabine in a rat orthotopic pancreatic cancer model. J Hepatobiliary Pancreat Sci. レフェリー有・20(2): 206-213. 2013

 

(形成外科学)

80.   Kakudo N, Morimoto N, Ogawa T, Hihara M, Notodihardjo PV, Matsui M, Tabata Y, Kusumoto K, Angiogenic effect of platelet-rich plasma combined with gelatin hydrogel granules injected into murine subcutis. J Tissue Eng Regen Med.  レフェリー有 Epub ahead of print.2016

*81.  Hara T, Kakudo N, Morimoto N, Horio O, Ogura T, Kusumoto K, Effect of aging on the osteoinductive activity of recombinant human bone morphogenetic protein-2 in rats. J Surg Res  レフリー有 195(1):377-383,2015.

*82.   Notodihardjo PV, Morimoto N, Kakudo N, Matsui M, Sakamoto M, Liem PH, Suzuki K, Tabata Y, Kusumoto K, Gelatin hydrogel impregnated with platelet-rich plasma releasate promotes angiogenesis and wound healing in murine model. J Artif Organs レフリー有 18(1):64-71,2015.

*83.  Kakudo N, Morimoto N, Kushida S, Ogawa T, Kusumoto K, Platelet-rich plasma releasate promotes angiogenesis in vitro and in vivo.  Med. mol. morphol. レフェリー有 47(2):83-89.2014

*84.   Notodiharjo FZ, Kakudo N, Kushida S, Suzuki K, Kusumoto K, Bone regeneration with BMP-2 and hydroxyapatite in critical-size calvarial defects in rats. J Cranio-Maxillofac Surg レフリー有 40(3):287-291,2012.

 

(眼科学)

85.   Shmueli RB1, Ohnaka M, Miki A, Pandey NB, Lima e Silva R, Koskimaki JE, Kim J, Popel AS, Campochiaro PA, Green JJ: Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide. Biomaterials レフェリー有 34(30):7544-51. 2013

86.   Ohnaka M, Miki K, Gong YY, Stevens R, Iwase T, Hackett SF, Campochiaro PA:Long-term expression of glial cell line-derived neurotrophic factor slows, but does not stop retinal degeneration in a model of retinitis pigmentosa. J Neurochem レフェリー有 122(5):1047-53. 2012

(整形外科学)

*87.  Nakamura T, Kushida T, Okamoto N, Oe K, Ikeura A, Li M, Ikehara S, Iida H. Induction of autoimmune arthritis after direct injection of bone marrow cells from arthritis-prone SKG/Jcl mice into bone cavity of normal mice: Bulletins of the Pharmaceutical Society. Biol Pharm Bull. 37(11):1719-26, 2014.

 

(救急医学)

88.   Nakano N, Nakai Y, Seo TB, Homma T, Yamada Y, Ohta M, Suzuki Y, Nakatani T, Fukushima M, Hayashibe M, Ide C, Effects of Bone Marrow Stromal Cell Transplantation through CSF on the Subacute and Chronic Spinal Cord Injury in Rats. PLoS ONE レフェリー有 8(9):2013 e73494. doi:10.1371

89.   Suzuki Y, Ishikawa N, Omae K, Hirai T, Ohnishi K, Nishida H, Tamura K, Nakano N, Nakatani T, Masanori Fukushima, and Chizuka Ide: Bone marrow-derived mononuclear cell transplantation in spinal cord injury patients by lumber puncture. Restor Neurol Neurosci. レフェリー有 32473-482,2014

 

(神経内科学)

*90.  Oki M, Kaneko S, Morise S, Takenouchi N, Hashizume H,Tsuge A, Nakamura M, Wate R, Kusaka H, Zonisamide ameliorates levodopa-induced dyskinesia and reduces expression of striatal genes in Parkinson model rats Neurosci Res レフェリー有(2017, in press)

91.   Nakamura S, Wate R, Kaneko S, Ito H, Oki M, Tsuge A, Nagashima M, Asayama S, Fujita K, Nakamura M, Maruyama H, Kawakami H, Kusaka H.  An autopsy case of sporadic amyotrophic lateral sclerosis associated with the I113TSOD1 mutation.  Neuropathology  レフェリー有 34(1):58-63 2014

92.   Nakamura M, Kaneko S, Ito H, Jiang S, Fujita K, Wate R, Nakano S, Fujisawa JI, Kusaka H.  Activation of Transforming Growth Factor-β/Smad Signaling Reduces Aggregate Formation of Mislocalized TAR DNA-Binding Protein-43. Neurodegener.Dis. レフェリー有 11(4):182-193 2013

93.   Nakamura M, Kaneko S, Wate R, Asayama S, Nakamura Y, Fujita K, Ito H, Kusaka H. Regionally different immunoreactivity for Smurf2 and pSmad2/3 in TDP-43-positive inclusions of amyotrophic lateral sclerosis. Neuropathol Appl Neurobiol.  レフェリー有 39(2):144-156 2013

94.   Neumann M, Valori CF, Ansorge O, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ishihara K, Ang LC, Bilbao JM, Mackenzie IR.  Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.  Acta neuropathol. レフェリー有 124(5):705-716 2012

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