RESEARCH

Cell Biology

Research Summary

The protocadherin family is a major sub-branch of the cadherin superfamily, whose members have six or seven cadherin motifs in their extracellular domain. Protocadherins are expressed in some specific neural pathways, and they seem to be involved in neural circuit formation and synaptic plasticity. It is notable that some protocadherin genes were shown to be susceptibility genes of autism. We are currently analyzing phenotypes of some protocadherin-knock-out mice to elucidate their roles in the nervous system.

References;
Suzuki & Hirano (Eds), The cadherin superfamily, Springer 2016
Hirano & Takeichi, Physiol. Rev. 2012
Asahina et al. Neurosci. 2012