RESEARCH

Comparative Pathology

Research Summary

Much of the research effort in our laboratory focuses on the viral and chemical mechanisms of mammary carcinogenesis and how they are influenced by host factors. Our ongoing oncologic studies include the identification of natural carcinogenic modifiers, mainly targeting breast cancer. We also seek to elucidate the mechanisms of parity protection against breast cancer, which has been shown in epidemiological studies. We found that N-methyl-N-nitrosourea caused photoreceptor apoptosis in several animal species, and we used this finding to establish animal models of human retinitis pigmentosa. By using these models, we are working to elucidate the mechanisms of disease progression and disease suppression. To accomplish these purposes, the members of our laboratory must be highly skilled at experimental animal techniques and cell culture. Additionally, the mastery of immunohistochemistry and molecular biological techniques is necessary to expand our morphology-based research. The establishment of animal models is essential for the better understanding of human disease. After joining our laboratory, you will share human autopsy and biopsy duties. You must participate in the journal club and research progress meetings to develop not only a scientific understanding of the world, but also the scientific knowledge necessary to work as a medical researcher. Your work as a scientist does not simply end after performing experiments; questions from human cases should be resolved in experiments, and experimental data should always extrapolate to humans.