Gastroenterology and Hepatology

Research Summary

Our laboratory focuses on not only common digestive disorders but also intractable ones. To develop novel diagnostic methods and treatments, our laboratory participates in Research on Measures for Intractable Diseases organized by the Ministry of Health, Labour and Welfare. To this end, we have the following committees:
  • Research Committee for Intractable Pancreatic Disorders 
  • Research Committee for Intractable Bowel Disorders
  • Research Committee for Intractable Hepatobiliary Disorders
  • Research Committee for the Development of Novel Treatment of Intractable Bowel Disease and Small Intestinal Ulcer
  • Research Committee for IgG4-related Disorders

Our laboratory consists of six research groups that focus on upper digestive disorders, small intestinal disorders, large intestinal disorders, hepatic disorders, biliary disorders, or pancreatic disorders.

Research on Upper Digestive Disorders
  • Mechanism of onset of Helicobacter pylori-related gastritis
  • Analysis of the host immune response
  • Role of intestinal stem cells in injured mucosal healing
  • Effect of antioxidants on injured mucosal healing
  • Clinical research on gastric cancer and reflux esophagitis

Research on Small Intestinal Disorders
  • Pathophysiological analysis of Crohn’s disease, non-specific ulcer of the small intestine, and nonsteroidal anti-inflammatory drug-related disorders

Research on Large Intestinal Disorders

  • Pathophysiological analysis and development of novel treatment (e.g., drug delivery system) for inflammatory bowel disease (IBD)
  • Role of enteric bacteria and innate immune system in the onset of IBD
  • Effect of microsatellite instability on large intestinal carcinogenesis

Research on Hepatic Disorders
  • Mechanism of hepatic fibrosis, hepatic carcinogenesis, and autoimmune hepatic disorders

Research on Biliary Disorders
  • Endoscopic diagnostic method to detect biliary and pancreatic disorders
  • Endoscopic stent method to detect biliary obstruction
  • Double balloon endoscopic retrograde cholangiopancreatography to detect biliary disorders in patients with post-reconstructive surgery

Research on Pancreatic Disorders
  • Preparation of diagnostic criteria and guidelines for autoimmune pancreatitis
  • Mechanism of pathogenesis of autoimmune pancreatitis
  • Basic/clinical research on the mechanism of IgG4 production