RESEARCH

Pathology and Laboratory Medicine

Research Summary

Introduction of our department
Our department consists of surgical pathology and clinical laboratory divisions. The division of surgical pathology is responsible for the histological diagnosis of biopsies, surgical resections, and cytological materials. All materials are signed out by two certified pathologists. The immunohistochemistry laboratory provides a comprehensive and extensive array of antibodies.
The division of clinical laboratory provides the high quality data. To improve the quality of our laboratory, our clinical laboratory archived and maintained ISO15189 certification.
 
Introduction of our research
In clinical laboratory division, we mainly analyze the endogenous digitalis-like factors for mechanism of hypertension with ELISA. We also developed the clinical tests for thrombocytopenia especially thrombotic thrombocytopenic purpura, heparin induced thrombocytopenia and arteriosclerosis.
In surgical pathology division, we analyzed a factor considered to be useful in treatment decision and the prognostic impact based on histology and immunohistochemistry.
Now we construct the tissue microarray blocks for representative tumors to perform the high throughput analyses with immunohistochemistry and RNA in situ hybridization. We recently developed a new technology “Digital immunostaining” as high sensitive and objective immunostaining method using fluorescence nanoparticles of phosphor-integrated dot. The novelty of this method is to count the protein expression level of each cell as digital fashion. The remarkable features of this technology are capability to quantify the protein expression level on formalin-fixed paraffin-embedded tissue with highly-sensitive and accurate manner.
 
Scope for our laboratory
Our aim is development of the more objective methods to resolve a question in daily practice with immunohistochemistry and molecular technic.
 
Theme for research
  1. Elucidation of the hypertension mechanism with the endogenous digitalislike substance
  2. To detect the predictive factor for patient care or prognostic factor with immunohistochemistry and molecular technic