RESEARCH

Stem Cell Biology

Research Summary

Recently, regenerative medicine attracts attention in a clinical field. It is well documented that hematopoietic stem cell (HSC) was widely used in HSC transplantation worldwide. Besides HSCs, the many cells, including epithelial cells, gastrointestinal mucosal cells, testicular germ cells, hepatocytes, pancreatic cells, nerve cells, skeletal muscle cells, cardiomyocytes and adipose tissue cells, are produced by a stem cell system. And the regeneration of various organ tissue using these tissue-committed stem cells (TCSC) comes into the limelight as a medical care in the near future. Moreover, these TCSCs sometimes exerted a phenomenon (plasticity) to differentiate across the germ layer. If this is true, an application of TCSCs in the regenerative medicine is more promising.
In this department, a main research project is the purification and characterization of very primitive human cord blood-derived CD34-negative HSCs. We also investigate another TCSCs, such as bone-derived small stem cells, and BM- and cord/placenta-derived mesenchymal stromal cells. In addition, we recently identified CD34-negative leukemic stem cells (LSCs) in various types of leukemia. Now we plan to produce specific monoclonal antibody against LSCs in order to eradicate these chemotherapy-resistant LSCs. 
The details of our research achievement and projects are introduced at the homepage (http://www3.kmu.ac.jp/hygiene/index.html).