Acute Critical Medicine, Traumatology and Disaster Medicine

Research Summary

Several animal models have been introduced in an attempt to assess the relationship between systemic oxygen consumption (VO2) and oxygen delivery (DO2) in vivo, and each model has unique characteristics, especially in the method used to reduce systemic DO2. We used artificial cardiac tamponade to reduce DO2, as was originally reported in a dog model by Nelson et al. This technique appears to have less impact on both blood volume and blood oxygen content, each of which may affect oxygen extraction capabilities. We developed a small animal (rabbit) model that takes advantage of artificial cardiac tamponade.