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参画部門・成果論文

医科学講座

  • 教授 小林 拓也


薬理学講座

  • 教授 中邨 智之
  • 准教授 赤間 智也

成果論文

  1. Tsutsumiuchi, M., Hoshino,H., Kogami, A., Tsutsumiuchi, T., Yokoyama, O., Akama, T.O., M. Kobayashi, M., Preferential expression of sialyl 6’-sulfo N-acetyllactosamine-capped O-glycans on high endothelial venules in human peripheral lymph nodes. Lab. Invest. 99, 1428-1441 (2019)


微生物学講座

  • 教授 藤澤 順一

成果論文

  1. H. Katsuya, S. Islam, B. J. Y. Tan, J. Ito, P. Miyazato, M. Matsuo, Y. Inada, S. C. Iwase, Y. Uchiyama, H. Hata, T. Sato, N. Yagishita, N. Araya, T. Ueno, K. Nosaka, M. Tokunaga, M. Yamagishi, T. Watanabe, K. Uchimaru, J.-I. Fujisawa, A. Utsunomiya, Y. Yamano, and Y. Satou . The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach. Cell Reports, 2019, 29, 3, 724–735.
  2. J. Yao, M. Tanaka, N. Takenouchi, Y. Ren, S.-I. Lee, J.-I. Fujisawa. Induction of APOBEC3B cytidine deaminase in HTLV-1-infected humanized mice. Induction of APOBEC3B cytidine deaminase in HTLV-1-infected humanized mice. Exp Ther Med, 2019, 17, 5, 3701-3708.


iPS・幹細胞再生医学講座

  • 教授 人見 浩史
  • 研究教授 服部 文幸
  • 准教授 藤岡 龍哉

成果論文

  1. S. Nishimoto, T. Mizuno, K Takahashi, F. Nagano, Y. Yuzawa, A. Nishiyama, K. Osafune, H. Hitomi, and T. Nagamatsu, CD140b and CD73 are markers for human induced pluripotent stem cell-derived erythropoietin-producing cells, FEBS openbio, Epub ahead of print, doi: 10.1002/2211/5463.12800, 2020


分子遺伝学部門

  • 教授 木梨 達雄

成果論文

  1. Konishi Y, Terai K, Furuta Y, Kiyonari H, Abe T, Ueda Y, Kinashi T, Hamazaki Y, Takaori-Kondo A, Matsuda M. Live-Cell FRET Imaging Reveals a Role of Extracellular Signal-Regulated Kinase Activity Dynamics in Thymocyte Motility, iScience. 2018 Dec 21;10:98-113.
  2. Bogdanova D, Takeuchi A, Ozawa M, Kanda Y, Rahman MA, Ludewig B, Kinashi T, Katakai T.  Essential Role of Canonical NF-κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs, J Immunol. 2018 Dec 15;201(12):3580-3586.
  3. Kanda Y, Takeuchi A, Ozawa M, Kurosawa Y, Kawamura T, Bogdanova D, Iioka H, Kondo E, Kitazawa Y, Ueta H, Matsuno K, Kinashi T, Katakai T. Visualizing the Rapid and Dynamic Elimination of Allogeneic T Cells in Secondary Lymphoid Organs. J Immunol. 2018 ;201(3):1062-1072.
 

生体情報部門

  • 准教授 松田 達志


侵襲反応制御部門

  • 学長特命教授 廣田 喜一
  • 講師 松尾 禎之

成果論文

  1. H. Bono, K. Hirota, Meta-analysis of hypoxic transcriptomes from public databases, bioRxiv (2019) 267310. https://doi.org/10.1101/267310.
  2. T. Shoji, M. Hayashi, C. Sumi, M. Kusunoki, T. Uba, Y. Matsuo, H. Kimura, K. Hirota, Pharmacological polysulfide suppresses glucose-stimulated insulin secretion in an ATP-sensitive potassium channel-dependent manner. Sci Rep 9 (2019) 19377. 10.1038/s41598-019-55848-7.
  3. M. Kusunoki, M. Hayashi, T. Shoji, T. Uba, H. Tanaka, C. Sumi, Y. Matsuo, K. Hirota, Propofol inhibits stromatoxin-1-sensitive voltage-dependent K(+) channels in pancreatic beta-cells and enhances insulin secretion, PeerJ 7 (2019) e8157. 10.7717/peerj.8157.
  4. H. Tanaka, Y. Matsuo, N. So, K. Nishi, A. Okamoto, S. Kai, T. Iwai, Y. Tabata, T. Tajima, Y. Komatsu, M. Sato, K. Kryukov, T. Imanishi, K. Hirota, Real-time diagnostic analysis of MinIONTM-based metagenomic sequencing in clinical microbiology evaluation: a case report, JA Clinical Reports 5 (2019) 24.
  5. C. Sumi, Y. Matsuo, M. Kusunoki, T. Shoji, T. Uba, T. Iwai, H. Bono, K. Hirota, Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma, PLoS ONE 14 (2019) e0215072. 10.1371/journal.pone.0215072.
  6. K. Hirota, An intimate crosstalk between iron homeostasis and oxygen metabolism regulated by the hypoxia-inducible factors (HIFs), Free Radic Biol Med 133 (2019) 118-129. 10.1016/j.freeradbiomed.2018.07.018.
  7. S. Kai, Y. Matsuo, S. Nakagawa, K. Kryukov, S. Matsukawa, H. Tanaka, T. Iwai, T. Imanishi, K. Hirota, Rapid bacterial identification by direct PCR amplification of 16S rRNA genes using the MinION nanopore sequencer, FEBS Open Bio 9 (2019) 548-557. 10.1002/2211-5463.12590.
  8. 甲斐 慎一, 松尾 禎之, 広田 喜一 MinIONTMを使ったクリニカルシークエンシングが拓く病原菌同定の新スタンダード:オンサイトでの感染症診断を可能にする超小型シークエンシングシステム, Intensivist 11 (2019) 386-390.


ゲノム解析部門

  • 学長特命教授 日笠 幸一郎


内科学第一講座

  • 教授 野村 昌作
  • 准教授 伊藤 量基

成果論文

  1. Tanaka A, Ito T, Kibata K, Inagaki-Katashiba N, Amuro H, Nishizawa T, Son Y, Ozaki Y, Nomura S. Serum high-mobility group box 1 is correlated with interferon-α and may predict disease activity in patients with systemic lupus erythematosus. Lupus. 2019 Aug;28(9):1120-1127. doi: 10.1177/0961203319862865. Epub 2019 Jul 12.
  2. Kibata K, Ito T, Inaba M, Tanaka A, Iwata R, Inagaki-Katashiba N, Phan V, Satake A, Nomura S. The immunomodulatory-drug, lenalidomide, sustains and enhances interferon-α production by human plasmacytoid dendritic cells. J Blood Med. 2019 Jul 12;10:217-226. doi: 10.2147/JBM.S206459. eCollection 2019.

 

内科学第三講座

  • 教授 岡崎 和一(~2020.3/31)
  • 教授 長沼 誠(2020.4/1~)

成果論文

  1. Ito T, Kawa S, Matsumoto A, Kubota K, Kamisawa T, Okazaki K, Hirano K, Hirooka Y, Uchida K, Masuda A, Ohara H, Shimizu K, Arakura N, Masamune A, Kanno A, Sakagami J, Itoi T, Ito T, Ueki T, Nishino T, Inui K, Mizuno N, Yoshida H, Sugiyama M, Iwasaki E, Irisawa A, Shimosegawa T, Chiba T. Risk Factors for Pancreatic Stone Formation in Type 1 Autoimmune Pancreatitis: A Long-term Japanese Multicenter Analysis of 624 Patients. Pancreas. 2019;48:49-54. doi: 10.1097/MPA.0000000000001210.
  2. Kamisawa T, Nakazawa T, Tazuma S, Zen Y, Tanaka A, Ohara H, Muraki T, Inui K, Inoue D, Nishino T, Naitoh I, Itoi T, Notohara K, Kanno A, Kubota K, Hirano K, Isayama H, Shimizu K, Tsuyuguchi T, Shimosegawa T, Kawa S, Chiba T, Okazaki K, Takikawa H, Kimura W, Unno M, Yoshida M.  Clinical practice guidelines for IgG4-related sclerosing cholangitis.  J Hepatobiliary Pancreat Sci. 2019 Jan;26(1):9-42. doi: 10.1002/jhbp.596.
  3. Wallace ZS, Zhang Y, Perugino CA, Naden R, Choi HK, Stone JH; ACR/EULAR IgG4-RD Classification Criteria Committee.  Clinical phenotypes of IgG4-related disease: an analysis of two international cross-sectional cohorts.  Ann Rheum Dis. 2019 Mar;78(3):406-412. doi: 10.1136/annrheumdis-2018-214603.
  4. Aoi K, Nishio A, Okazaki T, Takeo M, Masuda M, Fukui T, Uchida K, Okazaki K.  Inhibition of the dephosphorylation of eukaryotic initiation factor 2α ameliorates murine experimental pancreatitis.  Pancreatology. 2019 Jun;19(4):548-556. doi: 10.1016/j.pan.2019.04.005
  5. Nakamura T, Satoh-Nakamura T, Nakajima A, Kawanami T, Sakai T, Fujita Y, Iwao H, Miki M, Masaki Y, Okazaki T, Ishigaki Y, Kawano M, Yamada K, Matsui S, Saeki T, Kamisawa T, Yamamoto M, Hamano H, Origuchi T, Hirata S, Tanaka Y, Tsuboi H, Sumida T, Okazaki K, Tanaka M, Chiba T, Mimori T, Umehara H.  Impaired expression of innate immunity-related genes in IgG4-related disease: A possible mechanism in the pathogenesis of IgG4-RD.  Mod Rheumatol. 2019;11:1-7. doi: 10.1080/14397595.2019.1621475.
  6. Miyoshi H, Kano M, Kobayashi S, Ito T, Masuda M, Mitsuyama T, Nakayama S, Ikeura T, Shimatani M, Uchida K, Takaoka M, Okazaki K.  A Case of Diffuse Pancreatic Cancer Mimicking Autoimmune Pancreatitis.  Intern Med. 2019;58(17):2523-2527.: 10.2169/internalmedicine.2689-19.
  7. Okazaki K. Autoimmune Pancreatitis and IgG4-Related Disease: The Storiform Discovery to Treatment. Dig Dis Sci. 2019 Sep;64(9):2385-2394. doi: 10.1007/s10620-019-05746-9.
  8. Wallace ZS, Naden RP, Chari S, Choi H, Della-Torre E, Dicaire JF, Hart PA, Inoue D, Kawano M, Khosroshahi A, Kubota K, Lanzillotta M, Okazaki K, Perugino CA, Sharma A, Saeki T, Sekiguchi H, Schleinitz N, Stone JR, Takahashi N, Umehara H, Webster G, Zen Y, Stone JH; American College of Rheumatology/European League Against Rheumatism IgG4-Related Disease Classification Criteria Working Group. The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease. Arthritis Rheumatol. 2020 Jan;72(1):7-19. doi: 10.1002/art.41120.
  9. Wallace ZS, Naden RP, Chari S, Choi HK, Della-Torre E, Dicaire JF, Hart PA, Inoue D, Kawano M, Khosroshahi A, Lanzillotta M, Okazaki K, Perugino CA, Sharma A, Saeki T, Schleinitz N, Takahashi N, Umehara H, Zen Y, Stone JH; Members of the ACR/EULAR IgG4-RD Classification Criteria Working Group. The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease. Ann Rheum Dis. 2020 Jan;79(1):77-87. doi: 10.1136/annrheumdis-2019-216561.
  10. Kawa S, Kamisawa T, Notohara K, Fujinaga Y, Inoue D, Koyama T, Okazaki K. Japanese Clinical Diagnostic Criteria for Autoimmune Pancreatitis, 2018: Revision of Japanese Clinical Diagnostic Criteria for Autoimmune Pancreatitis, 2011. Pancreas. 2020 Jan;49(1):e13-e14. doi: 10.1097/MPA.0000000000001443.
  11. Masamune A, Kikuta K, Hamada S, Tsuji I, Takeyama Y, Shimosegawa T, Okazaki K; Collaborators.  Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2016. J Gastroenterol. 2019 Dec 23. doi: 10.1007/s00535-019-01658-7. [Epub ahead of print]
  12. Tsukuda S, Ikeura T, Ito T, Nakamaru K, Masuda M, Hori Y, Ikemune M, Yanagawa M, Tanaka T, Tomiyama T, Yamaguchi T, Ando Y, Uchida K, Fukui T, Nishio A, Terasawa R, Tanigawa N, Okazaki K.  Clinical implications of elevated serum interleukin-6 in IgG4-related disease.  PLoS One. 2020 Jan 17;15(1):e0227479. doi: 10.1371/journal.pone.0227479. eCollection 2020.


小児科学講座

  • 教授 金子 一成
  • 准教授 辻 章志


耳鼻咽喉科・頭頸部外科学講座(歯科・口腔外科含む)

  • 教授 岩井 大
  • 准教授 神田 晃
  • 講師 澤田 俊輔

成果論文

  1. Yun Y, Kanda A, Kobayashi Y, Van Bui D, Suzuki K, Sawada S, Baba K, Yagi M, Asako M, Okazaki H, Ikeda H, Kawamura S, Nakamura A, Dombrowicz D, Tomoda K, Iwai H. Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings. Allergol Int. 2020 Jan 9. pii: S1323-8930(19)30194-7
  2. Kanda A, Yasutaka Y, Van Bui D, Suzuki K, Sawada S, Kobayashi Y, Asako M, Iwai H. Multiple Biological Aspects of Eosinophils in Host Defense, Eosinophil-Associated Diseases, Immunoregulation, and Homeostasis: Is Their Role Beneficial, Detrimental, Regulator, or Bystander? Biol Pharm Bull. 2020;43(1):20-30.
  3. Kuwahara T, Kobayashi Y, Yun Y, Kanda A, Asako M, Ueki S, Iwai H. Eosinophilic Cholecystitis Occurred in a Patient With Refractory Eosinophilic Airway Inflammation: A Case Report. Allergy Rhinol (Providence). 2019 Aug 19;10:2152656719869607
  4. Bui DV, Kanda A, Kobayashi Y, Sakata Y, Kono Y, Kamakura Y, Jinno T, Yun Y, Suzuki K, Sawada S, Asako M, Nakamura A, Dombrowicz D, Utsunomiya K, Noboru T, Tomoda K, Iwai H. A Novel Approach for Investigating Upper Airway Hyperresponsiveness Using Micro-CT in Eosinophilic Upper Airway Inflammation such as Allergic Rhinitis Model. Biomolecules. 2019 Jun 27;9(7). pii: E252.
  5. 1. Kobayashi Y, Konno Y, Kanda A, Yamada Y, Yasuba H, Sakata Y, Fukuchi M, Tomoda K, Iwai H, Ueki S. Critical role of CC」L4 in eosinophil recruitment into the airway. Clin Exp Allergy. 2019 Jun;49(6):853-860.


皮膚科学講座

  • 教授 岡本 祐之(~2020.3/31)
  • 教授 谷崎 英昭(2020.4/1~)
  • 准教授 神戸 直智(~2020.3/31)

成果論文

  1. Kishimoto I, Nguyen CTH, Kambe N, Ly NTM, Ueki Y, Ueda-Hayakawa I, Okamoto H. Circulating intermediate monocytes produce TARC in sarcoidosis. Allergol Int. 2019 Oct 26. pii: S1323-8930(19)30162-5. [Epub ahead of print]


モデル動物部門

  • 講師 村山 正承

成果論文

  1. Arimitsu N, Murayama MA, Suzuki N, et al., Roles of Reelin/Disabled1 pathway on functional recovery of hemiplegic mice after neural cell transplantation; Reelin promotes migration toward motor cortex and maturation to motoneurons of neural grafts. Exp Neurol. 2019; 320: 112970.
  2. Tomochika K, Murayama MA, Suzuki N, et al., Transplantation of Human iPS Cell-derived Neural Cells with an Artificial Nerve Conduit Leads to Cellular Retention in the Transplanted Area and Improves Motor Function in a Mouse Spinal Cord Injury Model. J. St. Marianna Univ. 2019; 10(2): 27-37.
  3. Shimizu J, Murayama MA, Suzuki N. Relationship between skewed T cell differentiation and gut microbiota alternation in human immunological disorders. Precision Medicine. 2019; 2(4): 364-368. Japanese.
  4. Shimizu J, Murayama MA, Suzuki N. Relationship between skewed T cell differentiation and gut microbiota alternation in human immunological disorders. The Allergy in Practice. 2019; 38(7): 599-603. Japanese.
  5. Murayama MA. (Corresponding author). The pathogenic role of the complement activation in the development of osteoarthritis. BIO Clinica. 2019; 34(8): 852-853. Japanese.
  6. Murayama MA. (Corresponding author). Complement system as a therapeutic target for osteoarthritis. Precision Medicine. 2019; 2(11): 1086-1087. Japanese.
  7. Shimizu J, Murayama MA, Suzuki N. Relationship between skewed T cell differentiation and gut microbiota alternation in human immunological disorders. Agricultural Biotechnology. 2019; 3(13). 1260-1264. Japanese.

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